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. 2019 Apr 5;9:5734. doi: 10.1038/s41598-019-41934-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Gene set enrichment network designed using Cytoscape (as described in material and methods), comparing normal versus breast tumoral tissue (all breast cancer subtypes). GeneSets overexpressed in the tumoral phenotype are displayed in shades of orange-red; and those overexpressed in the normal phenotype are displayed in shades of blue. (B) ES Score profile and locations of “FOXM1 pathway” and “BRD proteins” members on the rank ordered list. Positive NES defines tumoral phenotype enrichment. (C) 3D structure of the common BRD domain shared by all the proteins coded by these genes, and subclassification of the BRD proteins into their families.