Table 2.
Power for quantitative incidence and prognosis without non-genetic confounding
| Genetic correlation | 0 | 0 | 0.25 | 0.25 | 0.45 | 0.45 | −0.25 | −0.25 | −0.45 | −0.45 |
|---|---|---|---|---|---|---|---|---|---|---|
| Adjustment | No | Yes | No | Yes | No | Yes | No | Yes | No | Yes |
| All SNPs not affecting prognosis | 5.00 | 5.00 | 5.01 | 5.04 | 5.03 | 5.13 | 5.01 | 5.03 | 5.03 | 5.12 |
| All SNPs affecting incidence but not prognosis | 5.00 | 5.01 | 5.17 | 5.72 | 5.61 | 7.30 | 5.18 | 5.64 | 5.61 | 7.20 |
| SNP with highest type-1 error | 8.02 | 8.02 | 8.50 | 15.2 | 13.0 | 35.6 | 8.30 | 13.7 | 13.4 | 33.7 |
| Family-wise type-1 error | 4.50 | 3.90 | 4.90 | 8.80 | 8.00 | 24.7 | 5.30 | 9.20 | 7.80 | 22.1 |
| All SNPs affecting prognosis | 16.6 | 16.6 | 16.2 | 15.6 | 15.1 | 13.3 | 16.2 | 15.6 | 15.1 | 13.3 |
| All SNPs affecting incidence and prognosis | 16.4 | 16.4 | 15.4 | 14.4 | 13.0 | 9.75 | 15.4 | 14.5 | 12.9 | 9.86 |
| SNP with greatest increase in power | 31.2 | 33.3 | 25.1 | 36.4 | 9.20 | 13.9 | 18.6 | 29.4 | 6.70 | 10.7 |
| SNP with greatest decrease in power | 20.1 | 17.9 | 53.9 | 35.4 | 62.0 | 26.2 | 46.1 | 31.9 | 56.6 | 26.2 |
Parameters are as in Table 1 except that there are no common non-genetic factors of incidence and prognosis