Table 4.
Power for binary incidence and prognosis without non-genetic confounding
| Genetic correlation | 0 | 0 | 0.25 | 0.25 | 0.45 | 0.45 | −0.25 | −0.25 | −0.45 | −0.45 |
|---|---|---|---|---|---|---|---|---|---|---|
| Adjustment | No | Yes | No | Yes | No | Yes | No | Yes | No | Yes |
| All SNPs not affecting prognosis | 5.00 | 5.00 | 5.00 | 5.01 | 5.00 | 5.03 | 5.00 | 5.01 | 5.00 | 5.03 |
| All SNPs affecting incidence but not prognosis | 5.00 | 5.01 | 5.02 | 5.22 | 5.10 | 5.70 | 5.03 | 5.21 | 5.11 | 5.66 |
| SNP with highest type-1 error | 7.30 | 7.30 | 7.70 | 8.60 | 7.70 | 15.5 | 8.30 | 9.10 | 8.10 | 14.4 |
| Family-wise type-1 error | 3.50 | 3.70 | 4.40 | 5.20 | 5.60 | 10.1 | 4.80 | 5.50 | 5.60 | 9.10 |
| All SNPs affecting prognosis | 8.76 | 8.77 | 8.60 | 8.38 | 8.25 | 7.58 | 8.61 | 8.41 | 8.25 | 7.63 |
| All SNPs affecting incidence and prognosis | 8.71 | 8.72 | 8.38 | 8.00 | 7.66 | 6.45 | 8.39 | 8.04 | 7.66 | 6.51 |
| SNP with greatest increase in power | 13.6 | 14.9 | 13.9 | 18.1 | 5.90 | 7.80 | 8.40 | 12.5 | 5.80 | 7.80 |
| SNP with greatest decrease in power | 44.2 | 42.5 | 53.3 | 42.6 | 48.9 | 27.7 | 51.9 | 43.4 | 43.1 | 25.8 |
Parameters as in Table 3 except that that there are no common non-genetic factors of incidence and prognosis