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. 2019 Apr 5;10:1561. doi: 10.1038/s41467-019-09381-w

Table 4.

Power for binary incidence and prognosis without non-genetic confounding

Genetic correlation 0 0 0.25 0.25 0.45 0.45 −0.25 −0.25 −0.45 −0.45
Adjustment No Yes No Yes No Yes No Yes No Yes
All SNPs not affecting prognosis 5.00 5.00 5.00 5.01 5.00 5.03 5.00 5.01 5.00 5.03
All SNPs affecting incidence but not prognosis 5.00 5.01 5.02 5.22 5.10 5.70 5.03 5.21 5.11 5.66
SNP with highest type-1 error 7.30 7.30 7.70 8.60 7.70 15.5 8.30 9.10 8.10 14.4
Family-wise type-1 error 3.50 3.70 4.40 5.20 5.60 10.1 4.80 5.50 5.60 9.10
All SNPs affecting prognosis 8.76 8.77 8.60 8.38 8.25 7.58 8.61 8.41 8.25 7.63
All SNPs affecting incidence and prognosis 8.71 8.72 8.38 8.00 7.66 6.45 8.39 8.04 7.66 6.51
SNP with greatest increase in power 13.6 14.9 13.9 18.1 5.90 7.80 8.40 12.5 5.80 7.80
SNP with greatest decrease in power 44.2 42.5 53.3 42.6 48.9 27.7 51.9 43.4 43.1 25.8

Parameters as in Table 3 except that that there are no common non-genetic factors of incidence and prognosis