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. 2019 Apr 5;10:1582. doi: 10.1038/s41467-019-09418-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Role of FoxKs in the regulation of gene expression. a Immunoblotting of FoxK1 and FoxK2 from lysates of Control (NS siRNA) and FoxK1/K2 double knockdown (DKD) cells using siRNAs (two-tailed Student t-test, *P < 0.05; **P < 0.01; ***P < 0.001) (n = 4). All data are represented as mean ± SEM. b PCA plots of the transcriptome profiles of Control (Black), FoxK1 KD (Red), FoxK2 KD (Blue), and DKD (Green) cells. c Heatmap of top 50 most significantly changed genes among all groups. d Venn diagram showing the numbers of significantly regulated genes by insulin in Control and DKD cells (FDR < 0.25). e Volcano plot showing the distribution of differentially regulated genes by insulin stimulation with log-fold change in Control versus DKD fold change on X-axis and −log10 P value on Y-axis. f Top directionally regulated reactome pathways by insulin in Control but not DKD cells. g Heatmap of top 50 (up and down: each top 25 for each) differentially regulated by insulin in Control and DKD cells