Fig. 9. The attenuation effect of Lico A-mediated autophagy on liver injury induced by LPS/GalN in mice.

WT mice were intraperitoneally injected 3-MA (20 mg/kg) for 2 h, and then Lico A (100 mg/kg) with mice for twice at a 12-h (interval for 12 h), followed by subjected to LPS (10 μg/kg) /GalN (700 mg/kg). The survival rates of the mice (n = 10 / group) were observed within 24 h after LPS (10 μg/kg) and GalN (700 mg/kg) exposure. a Control and Lico A group; b LPS/GalN group; c 3-MA+LPS/GalN; d Lico A+LPS/GalN; e 3-MA+Lico A+LPS/GalN. Similar results were obtained from three independent experiments. All data are presented as means±SEM. ^##p < 0.01 vs. Control group; ^**p < 0.01 vs. LPS/GalN group; ^@p < 0.01 vs. LPS/GalN+3-MA group