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. 2019 Apr 5;9:5662. doi: 10.1038/s41598-019-42076-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A section of pancreatic adenocarcinoma with vascular invasion is evaluated for MUC4 expression. The primary tumor mass (A) is heterogenous for MUC4 expression, with some neoplastic cells demonstrating strong positive staining while others are negative. At higher power, MUC4 staining is intense within some neoplastic cells (B) and not expressed in others. Numerous tumor emboli are present within lymphatic vessels in this tissue section; essentially all neoplastic cells invading vascular structures are positive for MUC4, suggesting the antiserum recognizes tumor clones more likely to produce metastasis within the heterogenous neoplastic tissue.