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. 2019 Apr 5;10:1556. doi: 10.1038/s41467-019-09583-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — New conservation measures separate benign and deleterious variants. a Distribution of variant shared taxa (VST) for deleterious and benign human variants that have a matching allele in the raw MSA. For each of the 32 possible VST values that were found in the MSA analysis, the percentages of benign and deleterious variants are shown. VST values can only be calculated when a matching amino acid is found in the MSA, which defines the number of benign and deleterious variants that could be used for this plot (see methods for details on data). b The average shared taxa profiles (STP) of deleterious and benign variants (see methods for details on data)