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. 2019 Apr 5;9:5692. doi: 10.1038/s41598-019-42245-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PCC0208027 produced robust anti-tumor effects in NSCLC tumor xenograft models. PCC0208027 inhibited tumor growth of HCC827, NCI-H1975, and Calu-3 xenograft models. HCC827, NCI-H1975, and Calu-3 cells (4 × 10⁶ cells/mouse) were implanted into the right flank of each animal. PCC0208027 was administered orally once daily for 15 days at different dose levels. (a) Tumor volume (left) and tumor weight (right) were satisfactorily inhibited in HCC827 tumor xenograft model after treatment with PCC0208027. One mouse died on day 14 in erlotinib group. (b) Tumor volume (left) and tumor weight (right) were effectively inhibited in NCI-H1975 tumor xenograft model after treatment with PCC0208027 while there was no effect and one mouse died on day 14 in the erlotinib group. (c) Tumor volume (left) and tumor weight (right) exhibited dose-dependent decreases after treatment with PCC0208027 in Calu-3 tumor xenograft model. Columns, mean; bars, s.d. (n = 3). ^*P < 0.05, ^***P < 0.001, compared to the control group.