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. 2019 Apr 5;9:5692. doi: 10.1038/s41598-019-42245-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mechanism of PCC0208027 anti-tumor activity in NSCLC tumor xenograft models. Ki67 and p-EGFR (or p-HER2) positive cells was observed in the tumor tissue (brown-colored objects) (200×). (a) PCC0208027, erlotinib, and osimertinib strongly decreased the number of p-EGFR and Ki67 positive cells in tumor tissues in comparison to the control group in HCC827 xenograft model. (b) PCC0208027 and osimertinib strongly decreased the number of p-EGFR and Ki67 positive cells in tumor tissues in NCI-H1975 xenograft model. (c) PCC0208027 significantly reduce the number of p-HER2 and Ki67 positive cells in tumor tissues in comparison to the control group in Calu-3 xenograft model. Columns, mean; bars, ^***P < 0.001, compared to the control group.