Table 2.

Effect of PCC0208027 on NSCLC cell viability.

Cell lines	Characterization	IC50 (nM)
		PCC0208027	Erlotinib	Osimertinib	Poziotinib
HCC827	EGFR (Del E746_A750))	4.22 ± 0.51	3.71 ± 1.89	1.09 ± 0.22	1.72 ± 0.32
NCI-H1975	EGFR (L858R/T790M)	11.11 ± 4.39	>1,000	7.25 ± 2.30	8.78 ± 3.03
Calu-3	HER-2 (WT, amplified)	6.07 ± 0.29	>1,000	469.96 ± 7.30	2.47 ± 0.52
NCI-H1781	HER-2 (G776V, Cins)	5.97 ± 1.37	>1,000	842.3 ± 33.95	6.17 ± 0.42
A549	K-ras mutation (G12S)	>1,000	>1,000	>1,000	>1,000

Values are presented as mean ± s.d. (n = 3).