Table 3.

Summary statistics for 47 genetic associations identified in the UK Biobank reaching P < 5 × 10⁻⁸

TRAIT	SNP	Chr	BP (hg19)	EA/OA	Freq	BETA	SE	P	Gene region
L5 timing	rs1144566	1	182,569,626	C/T	0.970	0.096	0.014	8E-12	RGS16/RNASEL
L5 timing	rs113851554	2	66,750,564	T/G	0.057	0.133	0.011	2E-35	MEIS1 a
L5 timing	rs12991815	2	68,071,990	C/G	0.424	0.029	0.005	2E-09	C1D a
L5 timing	rs9369062	6	38,437,303	A/C	0.708	0.039	0.005	9E-14	BTBD9 a
L5 timing	rs4882315	12	38,458,906	T/C	0.507	0.027	0.005	2E-08	CPNE8/ALG10B
L5 timing	rs12927162	16	52,684,916	G/A	0.277	0.029	0.005	3E-08	TOX3 a
M10 timing	rs1973293	12	38,679,575	C/T	0.481	0.029	0.005	1E-09	CPNE8/ALG10B
Sleep duration	rs2660302	1	98,520,219	A/T	0.811	0.041	0.006	9E-12	DPYD
Sleep duration	rs113851554	2	66,750,564	G/T	0.943	0.110	0.011	2E-25	MEIS1 a
Sleep duration	rs62158170	2	114,082,175	G/A	0.217	0.054	0.006	3E-21	PAX8
Sleep duration	rs17400325	2	178,565,913	T/C	0.958	0.066	0.012	2E-08	PDE11A
Sleep duration	rs72828540	6	19,102,286	T/C	0.752	0.041	0.005	1E-13	LOC101928519
Sleep duration	rs9369062	6	38,437,303	C/A	0.292	0.033	0.005	2E-10	BTBD9 a
Sleep duration	rs2975734	8	10,090,097	C/G	0.561	0.027	0.005	1E-08	MSRA
Sleep duration	rs13282541	8	41,723,550	C/T	0.739	0.032	0.005	4E-09	ANK1
Sleep duration	rs2880370	8	105,987,057	A/T	0.670	0.028	0.005	2E-08	LRP12/ZFPM2
Sleep duration	rs800165	12	67,645,219	C/T	0.343	0.028	0.005	3E-08	CAND1
Sleep duration	rs10138240	14	63,353,479	G/C	0.514	0.029	0.005	7E-10	KCNH5
Sleep midpoint	rs11892220	2	231,691,067	T/A	0.339	0.029	0.005	3E-08	CAB39
Sleep efficiency	rs113851554	2	66,750,564	G/T	0.943	0.101	0.011	5E-22	MEIS1 a
Sleep efficiency	rs62158169	2	114,081,827	T/C	0.216	0.032	0.006	2E-08	PAX8
Sleep efficiency	rs17400325	2	178,565,913	T/C	0.958	0.074	0.012	2E-10	PDE11A
Sleep efficiency	rs13094687	3	52,450,043	G/A	0.315	0.029	0.005	1E-08	PHF7
Sleep efficiency	rs13080973	3	138,596,050	G/A	0.202	0.032	0.006	3E-08	FOXL2
No. sleep episodes	rs12714404	2	282,462	T/G	0.283	0.037	0.005	1E-12	ACP1/SH3YL1
No. sleep episodes	rs310727	3	4,336,589	T/C	0.475	0.026	0.005	3E-08	SUMF1/SETMAR
No. sleep episodes	rs55754932	3	87,847,754	C/A	0.284	0.037	0.005	2E-12	HTR1F
No. sleep episodes	rs9864672	3	137,076,353	T/C	0.522	0.029	0.005	2E-10	IL20RB/SOX14
No. sleep episodes	rs4974697	4	2,473,092	T/A	0.390	0.026	0.005	5E-08	RNF4
No. sleep episodes	rs7377083	4	102,708,997	A/C	0.430	0.029	0.005	2E-09	BANK1
No. sleep episodes	rs749100	5	63,307,862	A/G	0.582	0.033	0.005	9E-12	HTR1A/RNF180
No. sleep episodes	rs9341399	6	73,773,644	C/T	0.936	0.066	0.010	6E-12	KCNQ5
No. sleep episodes	rs1889978	6	124,771,233	C/T	0.485	0.027	0.005	5E-09	NKAIN2
No. sleep episodes	rs2141277	7	39,099,178	A/G	0.478	0.026	0.005	1E-08	POU6F2
No. sleep episodes	rs10233848	7	103,122,645	G/A	0.293	0.035	0.005	2E-11	RELN
No. sleep episodes	rs1124116	10	99,371,147	A/G	0.730	0.031	0.005	2E-09	HOGA1/MORN4
No. sleep episodes	rs4755731	11	43,685,168	G/A	0.431	0.028	0.005	3E-09	HSD17B12
No. sleep episodes	rs3751837	16	3,583,173	C/T	0.781	0.033	0.006	4E-09	CLUAP1
No. sleep episodes	rs8045740	16	20,262,776	G/T	0.868	0.052	0.007	6E-14	GPR139
No. sleep episodes	rs11078917	17	37,746,359	A/C	0.279	0.029	0.005	3E-08	NEUROD2
No. sleep episodes	rs11082030	18	35,501,739	T/C	0.725	0.030	0.005	8E-09	CELF4
No. sleep episodes	rs8098424	18	52,458,218	G/A	0.619	0.027	0.005	1E-08	RAB27B
No. sleep episodes	rs76753486	19	42,684,264	T/C	0.084	0.047	0.008	2E-08	DEDD2/ZNF526
No. sleep episodes	rs429358	19	45,411,941	T/C	0.848	0.036	0.007	4E-08	APOE
No. sleep episodes	rs12479469	20	61,145,196	A/G	0.342	0.031	0.005	4E-10	MIR133A2
Diurnal inactivity	rs17805200	9	13,764,434	C/T	0.272	0.031	0.005	5E-09	MPDZ/NFIB
Diurnal inactivity	rs7155227	14	63,365,094	T/G	0.523	0.033	0.005	2E-12	KCNH5

CHR chromosome, BP base-pair position (GRCh37/hg19), EA/OA effect allele/other allele, Freq effect allele frequency, SE standard error, L5 timing midpoint of least-active 5 h, M10 timing midpoint of most-active 10 h, No. sleep episodes number of nocturnal sleep episodes

^aLocus previously reported for restless legs syndrome³⁵