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. 2019 Apr 5;9:5685. doi: 10.1038/s41598-019-42107-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Establishing the neuroblast lincRNome. (a) Expression profiles of neural and chromaffin markers in the neuroblast samples (mean epxr. +/− SE). (b) GSEA results on a logFC ordered mRNA list, derived from differential expression analysis between neuroblasts and high-risk NB tumors, using neuroblast/HR NB specific gene sets. (c) Number and overlap of expressed lincRNAs in neuroblast and NB samples. (d) Volcano plot of differentially expressed lincRNAs between neuroblasts and high-risk neuroblastoma samples at q < 0.05. The orange dots represent upregulated genes (774 lincRNAs) in HR NB samples, whereas the blue dots depict genes with a lower abundance (912 lincRNAs).