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. 2019 Apr 5;9:5747. doi: 10.1038/s41598-019-42287-7

Table 2.

Information concerning the protein-protein interaction.

Gene symbol Description Betweenness centrality Degree In-degree Out-degree
GSN gelsolin 0.995319495 16 7 9
LDHA lactate dehydrogenase A 0.773504274 13 8 5
HSPA5 heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) 0.70978836 19 14 5
HPX hemopexin 0.564102564 8 4 4
HSP90AA1 heat shock protein 90 kDa alpha (cytosolic), class A member 1 0.288970289 15 14 1
APOA2 apolipoprotein A-II 0.273504274 6 3 3
CALR calreticulin 0.165628816 14 4 10
HSP90B1 heat shock protein 90 kDa beta (Grp94), member 1 0.131440781 13 5 8
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.051282051 4 2 2
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.029487179 11 1 10
VIM vimentin 0.020960521 11 5 6
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.013105413 13 11 2

Betweenness centrality, the center of the signal; the greater the value, the stronger the intermediate ability of a protein in signal transmission.

Degree, the number of proteins interacting with proteins in the network.

In-degree, the number of proteins upstream of the indicated protein.

Out-degree, the number of downstream proteins of the indicated protein.