Figure 6.

Descriptive of the generated data. (A) Median (black symbols) and interquartile range (black bars) of all ln(P) values are compatible with the experimental data for all exchangeable amide hydrogen, excluding those not covered by any fragment probed by the HDX-MS measurement (156, 187–190, and 248; see Fig. 5A). Values are computed from over 5000 independent minimizations that resulted in a cost C < 0.006. (B) For three positions, the distributions (histograms) of ln(P) are shown; the histograms show that the predicted ln(P) follows a multimodal distribution. The bars representing the interquartile range of the three residues are shown in the same color in (A). To see this figure in color, go online.