Figure 1.

Cell invasion. (A) 50 randomly selected trajectories over a time course of 4 h of control cells (left), lam-A-overexpressing cells (middle), and cells with 5-μm polystyrene beads (right). (B) Motile fraction of cells. The number of analyzed cells is noted in white. (C) Cell speed, measured between subsequent images (Δt = 5 min). (D) Directional persistence, measured on a timescale of 1 h. (E) Mean Euclidean invasion distance over the course of 1 h. ^∗p ≤ 0.05, ^∗∗p ≤ 0.01, ^∗∗∗p ≤ 0.001, χ-square test of independence of variables in a contingency table for motile fraction and Student’s t-test assuming unequal variances including the outliers for all other variables; n.s., not significant (p > 0.05). To see this figure in color, go online.