Figure 3.

Influence of cell rigidity on magnitude and polarity of cell forces. (A) Total contractility and (B) force polarity of control cells (blue, n = 33), lam-A-overexpressing cells (green, n = 33), and cells with 5-μm polystyrene beads (red, n = 30) embedded in collagen gels. For all box plots, the central line indicates the median, the edges of the box denote the first and third quartiles, and the whiskers extend to the maximum and minimal value not considered as an outlier. Outliers are plotted as individual points. ^∗p ≤ 0.05, ^∗∗p ≤ 0.01, Student’s t-test assuming unequal variances including the outliers; n.s., not significant (p > 0.05). To see this figure in color, go online.