Figure 5.

Influence of steric hindrance on cell morphology. (A) Maximal intensity projection image of a control cell (left), lam-A-overexpressing cell (middle), and a cell with a 5-μm polystyrene bead (right) embedded on a 1.2 mg/ml collagen gel. (B) Major cell axis length, (C) minor cell axis length, and (D) aspect ratio of control cells (blue, n = 33), lam-A-overexpressing cells (green, n = 33), and cells with 5-μm polystyrene beads (red, n = 30) embedded in collagen gels. ^∗p ≤ 0.05, Student’s t-test assuming unequal variances including the outliers; n.s., not significant (p > 0.05). To see this figure in color, go online.