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. 2018 Jun 7;176(8):1059–1078. doi: 10.1111/bph.14335

Figure 4.

Figure 4

Protective effects of AL‐8810 in an animal model of MS and in a mouse model of TBI. (A) and (B) demonstrate how AL‐8810 (AL) was able to reduce the loss of myelin (A) and thus help retain motor function (B) in a cuprizone (CPZ)‐induced mouse model of MS; (*P < 0.05 vs. control; #P < 0.05 vs. CPZ + saline; modified from Iwasa et al., 2014). (C) Shows the protective effects of AL‐8810 in a controlled cortical impact (CCI) traumatic injury model in mice. Note the improvement of grip strength in mice who received AL‐8810 versus the control saline group at 24 h post CCI (*P < 0.05 vs. control group; modified from Glushakov et al., 2013a,b).