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. 2019 Jan 18;47(6):2966–2980. doi: 10.1093/nar/gkz009

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — BRCA1^−/−, CtIP^{S332A/−/−} and nuclease-dead MRE11^D20A/− mutants exhibit increased number of ddC-induced chromosomal aberrations. (A) Schematic representation of the experimental protocol to measure chromosomal aberrations. (B) Representative images of chromatid damage (arrow) and isochromatid damage (arrowhead) after ddC treatment. (C) Number of damage per mitotic cells in the indicated genotypes (Upper panel). Error bars represent standard deviation. At least 50 mitotic cells were counted for each cell line. The P-value for Student's t-test was *P< 0.01. The subtracted numbers of damages before the exposure from damages after the exposure (Lower panel). Error bars represent standard deviation.