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. 2019 Jan 18;47(6):2966–2980. doi: 10.1093/nar/gkz009

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — An important role of BRCA1, CtIP and MRE11 for cellular tolerance to nucleoside analogs in human TK6 cells. (A) Cell survival rate to the indicated agents was analyzed as described in Figure 1A. (B) Representative images of chromatid damage (arrow) and isochromatid damage (arrowhead) after ddC treatment (upper panel). Number of damages per mitotic cells in the indicated genotypes (lower panel) was calculated as described in Figure 4C.