Table 3.

PG analogue sustained release combinations evaluated clinically

PG analogue	Sustained release platform	Highest phase (www.clinicaltrials.gov trial number)	Comment
Bimatoprost	Intracameral insert	Phase 3 recruiting (NCT02250651 and NCT02247804, timolol comparator; NCT02507687 and NCT02636946, laser trabeculoplasty comparator)	Phase 2 results published (Lewis et al., 2017)
Bimatoprost	Peri‐ocular ring	Phase 2 completed (NCT02358369)	–
Latanoprost	Subconjunctival insert	Phase 1 terminated (NCT01180062)	–
Latanoprost	Subconjunctival insert	Phase 2 ongoing (NCT02129673)	–
Latanoprost	Punctal plug	Phase 2 completed (NCT01481077)	–
Travoprost	Intracameral implant	Phase 2 recruiting (NCT02371746)	–
Travoprost	Punctal plug	Phase 3 recruiting (NCT02914509)	Phase 2 feasibility study Asian cohort results published (Perera et al., 2016)
Travoprost	Intraocular implant	Phase 2 ongoing (NCT02754596)	–