Table 1.
Available X-ray and NMR structures of the domains of each NOS isoform, along with the PMID associated to the corresponding publication in Pubmed and the corresponding entry in the Protein Data Bank (PDB). We did not report the structures of the heme domain in complex with inhibitors.
| Isoform | Organism | Domain structure | PDB ID | PMID |
|---|---|---|---|---|
| nNOS | Human | Heme | 4D1N | 25286850 |
| Rat | Heme | 4FVW, 3HSN, 2G6H, 1ZVI, 1LZX | 23586781, 19791770, 16804678, 16033258, 12437343 | |
| Reductase | 1TLL | 15208315 | ||
| FNR-like (FAD/NADPH) | 1F20 | 11473123 | ||
| iNOS | Human | Heme | 1NSI | 10409685 |
| calmodulin binding + calmodulin | 5TP6, 2LL6 | 28121131, 22486744 | ||
| FMN/calmodulin binding + calmodulin | 3HR4 | 19737939 | ||
| Mouse | Heme | 3NQS, 1DWV, 1DF1 | 20659888, 10769116, 10562539 | |
| Heme mutant | 3DWJ, 1JWJ | 18815130, 11669619 | ||
| eNOS | Human | Heme | 3NOS, 4D1O | 10074942, 25286850 |
| calmodulin binding + calmodulin | 2MG5, 2LL7, 2N8J, 1NIW | 24495081, 22486744, 27696828, 12574113 | ||
| Bovin | Heme | 1NSE, 2G6O, 1ED6 | 9875848, 16804678, 11331003 |