Fig. 4.

Effect of EPO treatment: network based statistics and core structure analysis. (a) structural connectivity network (FA_mean) with increased connection strength in EPO-treated neonates. The size of nodes correlates with the number of significantly positive edges arising from the node, while edge width correlates with the test statistic of the NBS analysis. Gray edges mean inter-modular, colored edges intra-modular or intra-lobar connections. LH: left hemisphere, RH: right hemisphere. (b) linear regression plot showing the relationship between average FA_mean of the significant graph edges, CGA at the time of MRI and group allocation. (c) network core affected by EPO treatment, NBS results, (d) common network core of the study population. In the middle image, core and peripheral nodes are depicted in red and yellow, respectively, while core connections, feeder connections and local connections are depicted as red, yellow and gray lines. For the abbreviations of ROIs, see Table S1.