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. 2019 Jan 30;47(6):e32. doi: 10.1093/nar/gkz037

Figure 3.

Figure 3.

Characterisation of triple helices forming lncRNAs during cardiac differentiation. (A) The strategy for identification of lncRNAs forming triple helices during cardiac differentiation. (B) Distribution of statistics used to rank lncRNAs according to their triplex-forming potential. (C) The expression profile of GATA6-AS. (D) TDF showing the presence of two domains in GATA6-AS, which were predicted to form a triplex in promoters of the up-regulated genes. (E) A de novo identified G-rich motif in 332 Domain I DBD-Capture-Seq peaks (out of 500 top-ranked peaks). (F) DBD logo indicating the nucleotides from the GATA6-AS domain sequence, which are predicted to form triple helices in GATA6-AS Capture-Seq peaks. (G) TDF analysis showing high propensity (higher z-score) of Domain I RNA to form triple helices in corresponding Capture-Seq peaks but not in control peaks. (H) Area under the precision recall curve (blue) associating the overlap of GATA6-AS-Domain I-Capture-Seq peaks with the promoters of genes (±1 kb) as ranked by TDF.