Table 3.

Risk factors associated with TD among patients with hepatitis C infection by univariate and multivariate Cox regression analyses

	Univariate analysis		Multivariate analysis
Variables	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P value
Sex (F/M)	1.46 (1.19–1.78)	< 0.001	1.49 (1.23–1.75)	< 0.001
PEG-IFN/RBV treatment (yes/no)	1.70 (1.40–2.07)	< 0.001	1.68 (1.38–2.06)	< 0.001
Hyperlipidemia (yes/no)	141 (1.16–1.72)	< 0.001	1.38 (1.12–1.71)	< 0.001
Past history of goiter (yes/no)	6.61 (5.18–8.43)	< 0.001	6.40 (5.00–8.18)	< 0.001

TD thyroid dysfunction, HR hazard ratio, CI confidence interval, M males, F females, PEG-IFN/RBV pegylated interferon/ribavirin, CKD chronic kidney disease

The dependent variable was thyroid dysfunction (yes/no). The available independent variables were age, sex, PEG-IFN/RBV treatment, hyperlipidemia, regional residence, hypertension, CKD, diabetes mellitus, liver cirrhosis, past history of goiter