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. 2019 Apr 5;20:272. doi: 10.1186/s12864-019-5621-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — SNVs and INDELS localization across the chIFITM proteins. chIFITM proteins are comprised of two exons separated by one intron. SNVs and INDELS locations from Table 3 are depicted in red (missense SNVs), green (silent SNVs) or in blue (INDELs) bars. An alternate structure is drawn for chIFITM2 and 3 as a result of the frameshift caused by the respective INDELs. Greyed exons represent mutated proteins as a result of the frameshift: in chIFITM2, the two frameshifts in exon 1 generate a novel protein which has lost the IM1 domain; in chIFITM3 the C59STOP generates a shorter protein, with exon 2 completely missing. Aa = amino acid, IM1 = intramembrane domain 1. Bold blue SNVs regarded to be deleterious for the protein as they would disrupt the overall structure (see structural data analysis for G72S and R77W)