Fig. 7.

Structural modelling of the chIFITM proteins. a chIFITM3 structure model embedded in a DOPC lipid bilayer. The structure was initially modelled based on the published topology of human IFITM3, and later refined by all-atom molecular dynamics. b Secondary structure prediction of the three chIFITM proteins according to PSIPRED. All proteins feature an N-terminal disordered domain followed by two short helices and one long C-terminal transmembrane helix. c Predicted structure of chIFITM1 and chIFITM2 based on the chFITM3 model. SNVs and positively selected residues identified in this study are highlighted