Table 4.
Gene methylation detection in plasma samples for cancer and controls
| Sensitivity | Specificity | PPV | NPV | AUC | |
|---|---|---|---|---|---|
| CA19-9 | 55.9% (19/34) | NA | NA | NA | NA |
| ADAMTS1 | 87.2% (34/39) | 95.8% (91/95) | 89/5% (34/38) | 95.8% (91/96) | 0.91 |
| BNC1 | 64.1% (25/39) | 93.7% (89/95) | 80.6% (25/31) | 86.4% (89/103) | 0.79 |
| ADAMTS1 and/or BNC1 | 97.4% (38/39) | 91.6% (87/95) | 82.6% (38/46) | 98.9% (87/88) | 0.95 |
| ADAMTS1 and/or BNC1 and/or CA19-9 | 97.4% (38/39) | NA | NA | NA | NA |
| ADAMTS1 + CA19-9 | 87.2% (34/39) | NA | NA | NA | NA |
| BNC1 + CA19-9 | 89.2% (33/37) | NA | NA | NA | NA |
N/A: Not applicable