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. 2019 Apr 5;20:61. doi: 10.1186/s12881-019-0793-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a The family pedigree is depicted. The proband (shown by arrow, II2) and her dizygotic twin sister (II3) were homozygous for the NM_000363.4:c.586G > C variant and displayed the phenotype of restrictive cardiomyopathy (RCM). Their brother (II1) also homozygous for the same variant displayed the phenotype of hypertrophic cardiomyopathy (HCM). Their children, with age range from 5 to 21 years old (III1: 5, III2: 13, III3 and III4: 21), remain unaffected along with the proband’s parents who were found heterozygous for the same mutation. Circle = female. Square = male. Filled symbols = affected individuals. b Electropherogram of the involved sequence fragment of the TNNI3 for the members of the family. The detected mutation is highlighted