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. 2019 Apr 5;38:148. doi: 10.1186/s13046-019-1133-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The effect of pemetrexed(P) and icotinib(I) on inducing apoptosis of PC-9 cells in vitro. a PC-9 cells were treated with incremental concentration levels of icotinib. b PC-9 cells were treated with incremental concentration levels of pemetrexed. c PC-9 cells were treated with pemetrexed with or without icotinib. The quantitative analysis was shown in the bar graphs. d The release of cytochrome C (cyto-C) was monitored by immunofluorescence analysis in PC-9 cells treated with pemetrexed with or without icotinib (400×). e The levels of the bcl-2, cleaved caspase-3, caspase-9 and PARP proteins were analyzed by Western blot in PC-9 cells treated with or without pemetrexed with or without icotinib. The quantitative analysis was shown in the bar graphs. Data are presented as mean ± SD of triplicate experiments, *p < 0.05