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. 2019 Apr 5;19:86. doi: 10.1186/s12935-019-0780-7

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 10 — Activation of the Akt signaling pathway by ST6GALNAC1 enables tumor cells to acquire stem cell stemness. ST6GALNAC1 promotes the phosphorylation of PI3K, Akt, and S6 and increases β-catenin transcription to activate the Akt signaling pathway and finally enables tumor cells to acquire stem cell stemness