Figure 3.

This is a brief summary about several PTMs of hnRNPK protein appear to coordinate to elicit a specific outcome. The left side of the figure shows that ERK phosphorylation of hnRNPK at S116 and T120 leads to ubiquitin-mediated degradation of hnRNPK; the right side of the figure shows that ATM-mediated phosphorylation at T174 and T440 can block ubiquitin-mediated degradation of hnRNPK. The figure shows that c-Src phosphorylation of hnRNPK at Y230, Y234 and Y236 enhances the PKCδ-mediated phosphorylation of S302 on hnRNPK; the chart below shows that PRMT1-mediated methylation at R296 and R299 can block the PKCδ-mediated phosphorylation of S302 on hnRNPK. P, phosphorylation; Me, methylation; Ub, ubiquitination.