Figure 3.

iRhoms in protein trafficking. A schematic of how iRhoms play an important role in the trafficking of the membrane proteins, ADAM17 (green) and STING (orange). On the left is an illustration of iRhom1 and 2 promoting the trafficking of ADAM17 from the ER to the Golgi apparatus, where the latter undergoes maturation by furin mediated cleavage to remove its prodomain. iRhoms further aid in the movement of ADAM17 from the Golgi to the plasma membrane, to promote shedding of TNF and EGFR ligands (blue). On the right is a depiction of iRhom2 facilitating the movement of STING from the ER to the microsomes via the Golgi, with the aid of TRAPβ (red).