Table 3.
Parameters of the rate equations used as the basis of the model.a
| biological process | parameter | value | units |
|---|---|---|---|
| cell wall binding | kcatCW | 1.23 | 1/min |
| cell wall binding | KCW | 9.07 × 109 | molecules/l |
| cell membrane binding | kcatCM | 0.205 | 1/min |
| cell membrane binding | KCM | 9.07 × 109 | molecules/l |
| toxin-induced cell death via primary pathway (K1 and K28) | LUPrimary | 28 000 | LU |
| toxin-induced cell death via apoptotic pathway (K1) | LUApoptotic(K1) | 825 | LU |
| toxin-induced cell death via apoptotic pathway (K28) | LUApoptotic(K28) | 1080 | LU |
| K1-induced death | kTID(K1) | 5.0 × 10−7 | l · min/molecules |
| K28-induced death | kTID(K28) | 2.5 × 10−13 | l · min/molecules |
| adjusted K1-induced death | kATID(K1) | 2.5 × 10−9 | l · min/molecules |
| K1-induced apoptosis | kTIA(K1) | 4.0 × 10−9 | l · min/molecules |
| K28-induced apoptosis | kTIA(K28) | 5.0 × 10−9 | l · min/molecules |
| K1-triggered apoptotic death | kAD(K1) | 0.30 | l · min/molecules |
| K28-triggered apoptotic death | kAD(K28) | 0.30 | l · min/molecules |
aIf the value of a parameter was obtained by parameter scanning, the median value is displayed above.