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. 2019 Mar 21;12(3):dmm038315. doi: 10.1242/dmm.038315

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Bulla mesenchyme condensation. (A) Bulla mesenchyme regresses after P10 in Fbxo11^+/+ but persists in Fbxo11^Jf/+ mice. Numbers adjacent to points indicate the number of bullae examined; numbers above the symbol are for Fbxo11^+/+ and those beneath are for Fbxo11^Jf/+ bullae. (B) Mesenchyme area and (C) mesenchymal nuclei density. C57BL/6J partially regressed mesenchyme (PART) has a reduced area compared with pre-regression mesenchyme (PRE), and its mesenchymal nuclei density is increased. Remnant P13 and P15 Fbxo11^Jf/+ mesenchyme shrinks and has increased nuclei density. (D) MAE to cochlea promontory length ratios and (E) epithelial nuclei densities. C57BL/6J partially regressed mesenchyme epithelium is shorter than pre-regression mesenchyme epithelium. C57BL/6J epithelial density increases from pre- to partially regressed mesenchyme and to promontory epithelium (PE). Fbxo11^Jf/+ bullae have persistent MAE and epithelial density is significantly increased at P15. Data in histograms (B-E) are represented as points and the median. Statistical tests were chosen after performing D'Agostino and Pearson omnibus normality tests. C57BL/6J data were analyzed with Student's t-tests, or ANOVA with Tukey's multiple comparison tests (except that MAE ratios were analyzed with a Mann–Whitney test). Fbxo11^Jf/+ data were analyzed with Kruskal–Wallis tests and Dunn's multiple comparisons using P11 data as the reference control. Two-tailed tests: **P<0.01, ***P<0.001, ****P<0.0001; all other comparisons were not statistically significant.