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. 2019 Mar 21;12(3):dmm038315. doi: 10.1242/dmm.038315

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Prevalence of otitis media in P105-P119 Fbxo11 mice and morphometric analysis of auditory-tube SMGs and auditory tubes. (A) The proportion of Fbxo11^Jf/+ bullae (n=12) with otitis media and mineralization and adhesions is high, but absent in Fbxo11^+/+ bullae (n=20). (B) Fbxo11^Jf/+ bulla mucosa is thickened. Cumulative areas of (C) auditory-tube SMGs and (D) auditory-tube lumen measured in 50-µm step sections are the same in Fbxo11^Jf^/+ and Fbxo11^+/+ bullae. The histogram bar in A represents the mean and the error bars 95% confidence interval for each proportion. Frequency data were analyzed with Fisher's exact tests. Data in graphs B-D are represented as points; the error bars are mean±s.e.m. Data was analyzed with Student’s t-tests. Two-tailed tests: ns, not significant (P>0.05), ***P<0.001, ****P<0.0001.