Table 4.
Chemical stability of dexamethasone sodium phosphate (DSP) with different 5-HT3 receptor antagonists (5-HT3RAs) in infusion solutions
| Admixture code* | Initial concentration (μg/mL) |
% of initial concentration remaining after 48 hours |
||
|---|---|---|---|---|
| DSP | 5-HT3RA | DSP | 5-HT3RA | |
| A | 91.8±1.0 | 74.5±0.9 | 101.2±0.1 | 101.5±0.2 |
| B | 181.3±2.1 | 72.2±0.8 | 101.2±0.1 | 101.4±0.2 |
| C | 92.7±1.1 | 74.5±0.9 | 101.6±0.2 | 99.9±0.1 |
| D | 179.6±1.8 | 72.4±0.5 | 99.1±0.1 | 99.9±0.1 |
| E | 99.1±0.4 | 50.5±0.5 | 99.2±0.1 | 99.3±0.2 |
| F | 198.3±2.2 | 50.1±0.4 | 100.5±0 | 99.0±0.4 |
| G | 91.4±1.2 | 924.6±8.5 | 99.6±0.8 | 99.7±1.0 |
| H | 185.1±1.1 | 918.1±7.9 | 100.0±0.6 | 98.8±0.3 |
| I | 91.2±0.9 | 916.6±10.1 | 99.1±0.7 | 99.0±0.5 |
| J | 188.2±1.5 | 934.6±10.6 | 98.8±0.5 | 99.1±0.7 |
| K | 98.9±0.5 | 198.7±2.6 | 97.5±0.5 | 99.3±0.4 |
| L | 197.7±2.4 | 197.9±2.3 | 97.4±0.4 | 99.7±0.4 |
| M | 90.2±2.1 | 2.3±0.1 | 98.9±0.9 | 100.1±0.3 |
| N | 181.4±2.9 | 2.2±0.1 | 99.5±1.2 | 99.8±0.3 |
| O | 90.8±1.3 | 2.3±0.0 | 98.7±1.2 | 99.2±1.0 |
| P | 182.1±2.6 | 2.3±0.1 | 99.1±1.6 | 99.4±1.1 |
| Q | 88.5±0.9 | 2.7±0.1 | 99.3±1.0 | 100.2±0 |
| R | 183.1±1.5 | 2.7±0.1 | 98.3±0.9 | 99.5±0 |
| S | 91.3±0.8 | 2.8±0.0 | 98.6±0.3 | 100.2±0.5 |
| T | 180.2±2.4 | 2.7±0.1 | 101.6±0.3 | 100.7±0 |
Results are expressed as mean±SD (n=3).
*Codes of admixtures are noted in table 2.