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. 2018 Dec 19;33(5):1113–1123. doi: 10.1038/s41375-018-0319-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Clonal phylogenies, inferred by maximum parsimony, and sub-clone genotypes in 10 patients. Genetically distinct sub-clone percentages (as a fraction of the total population) are indicated next to each clone; e.g., patient 1, most primitive sub-clone, CD34⁺/CD33⁻ first and CD33⁺/CD34^-/CD3⁻ second percentages indicated as 18%/5%, respectively. This indicates that this sub-clone was found in 18% of the total CD34⁺/CD33^- cells investigated and 5% of the total CD33⁺/CD34⁻/CD3⁻cells investigated (for the relapse samples of patients 9 and 10 only bulk cells without phenotype consideration could be sorted, as the samples available were from fixed cytogenetic preparations; the sub-clone is shown as a single percentage). Those sub-clones that grew in mice are indicated with horizontal black arrows. t1-3 (%). T, transplant. 1-3 individual mice. % fraction of human cells in mouse bone marrow. Sub-clone denoted by dotted circle is below detection limit in diagnostic sample but present in mouse transplant read-out. Dotted arrows lines between sub-clones (case #1 and #3) indicates alternative clonal phylogenies. In case #3, there are 4 possible equally parsimonious phylogenetic trees (details in Supplementary Information Figs. 5 and 6). Further details on each of the individual 10 patients’ clonal analyses are given in Supplementary Information