Table 3.

Animal characteristics at death or end of study between the swine treated with DMTS and saline control

Animals in the DMTS treatment arm return to breathing following apnea, whereas control animals do not. DMTS treatment results in increased survival time, improved blood lactate and pH, improved hemodynamics, pulse oximetry, and respiratory rate. Comparisons made at death/end of study due to control animals dying prior to the end of study.

	Control n=6	DMTS n=6	Difference between means	95% CI difference
Time to rebreathing post treatment (minutes)	0	19.3+10.0	19.3+4.1	8.8, 29.8
Time to death (minutes)	27+32.2	77.8+29.8	50.8+17.9	10.9, 90.8
Lactate (mmol/L)	9.41+5.69	4.35+2.10	−5.06+2.44	−10.94, 0.82
pH	7.20+0.20	7.37+0.09	0.17+0.09	−0.04, 0.38
Systolic blood pressure (mmHg)	27+10	86+27	59+11.7	30.6, 87.4
Mean arterial pressure (mmHg)	20+5	72+21	52+8.9	30.3, 74.3
Heart rate (beats per minute)	50.8+19.1	115.5+41.2	64.7+18.79	−44.5, 74.2
Respiratory rate (breaths per minute)	0+0	22.2+12.1	22.2+4.9	9.5, 34.9
Pulse oximetry (% oxygen)	44.5+3.8	81.2+12.2	36.7+5.2	23.9, 49.4
Systemic vascular resistance (dynes⋅sec⋅cm−5)	604.7+40.4	1069+398.9	464.3+164.5	46.7, 882.7

Data is presented as means + standard deviation.

mmol: millimole; L: liter; mmHg: millimeters of mercury; CI: confidence interval; DMTS: dimethyl trisulfide