Levels of THB-Gua-butadiene adducts (left panel) and bis-N7G-butadiene crosslinks (right panel) in tissues from female (gray bars) and male (black bars) mice exposed to 425 ppm of 1,3-butadiene. Data are presented as mean +/−SD. Asterisk, pound, and ampersand (*, #, and &) denote significant (p<0.05) differences in the levels of adducts or crosslinks between C57BL/6J or CAST/EiJ male and female mice, C57BL/6J and CAST/EiJ male mice, or C57BL/6J and CAST/EiJ female mice, respectively.