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Knockdown of SAG or ROC1 induced G2/M arrest, apoptosis, and senescence: RCC 786-0 and SLR20 cells were infected with LT-SAG or LT-ROC1 along with LT-CON for 72 hours, followed by FACS analysis (A), DNA fragmentation (B), β-gal staining (C), and Western blotting with indicated Abs (D). Shown are means ± S.E.M. from three independent experiments. *P < .05, **P < .01, ***P < .005, ****P < .001.
