. 2018 Oct 27;58(5):651–658. doi: 10.1007/s40262-018-0719-5

Table 3.

Effects of genotypes on parameter estimates

Factor	Compared genotypes	PK parameter	Parameter estimate (RSE %)	p value (ΔOFV)
ABCG2 421C > A	WT/WT vs. other	F CL	Other: F *1.02 WT/WT: 0.27 L/h, other: 0.28 L/h^a	0.78 (0.08)
ABCG2 421C > A	WT/WT vs. other	F CL	Other: F *1.02 WT/WT: 0.27 L/h, other: 0.28 L/h^a	0.67 (0.18)^a
ABCG2 34G >A	WT/WT vs. WT/var	F CL	WT/var: F *1.24 WT/WT: 0.27 L/h, WT/var: 0.26 L/h	0.17 (1.87)
ABCG2 34G >A	WT/WT vs. WT/var	F CL	WT/var: F *1.24 WT/WT: 0.27 L/h, WT/var: 0.26 L/h	0.86 (0.03)
ABCB1 3435C >T	WT/WT vs. other	F CL	Other: F *1.17^a WT/WT: 0.28 L/h, other: 0.27 L/h	0.21^a (1.58)
ABCB1 3435C >T	WT/WT vs. other	F CL	Other: F *1.17^a WT/WT: 0.28 L/h, other: 0.27 L/h	0.64 (0.22)
ABCB1 3435C >T	var/var vs. other	F CL	Var/var: F*1.01 Var/var: 0.28 L/h, other: 0.25 L/h	0.89 (0.02)
ABCB1 3435C >T	var/var vs. other	F CL	Var/var: F*1.01 Var/var: 0.28 L/h, other: 0.25 L/h	0.40 (0.71)
CYP3A422*	WT/WT vs. WT/var	F CL	Var: F*0.81 WT/WT: 0.27 L/h (23%), WT/var: 0.18 L/h (17%)	0.16 (2.00)
CYP3A422*	WT/WT vs. WT/var	F CL	Var: F*0.81 WT/WT: 0.27 L/h (23%), WT/var: 0.18 L/h (17%)	0.002 (9.47)

CL clearance, F bioavailability, ΔOFV difference in objective function value, PK pharmacokinetic, RSE relative standard error, var variant, WT wild type

^aNONMEM run unsuccessful because of rounding errors