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. 2018 Oct 17;58(5):627–637. doi: 10.1007/s40262-018-0715-9

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Exposure variability and covariates predicting variability. a Fludarabine plasma concentrations versus time after last dose on a logarithmic scale. Each line corresponds to a single dose, stratified to dose. b Histogram (grey area) and density plot (black solid line) of the observed AUC_T0−∞. AUC_T0−∞ of patients receiving a low dose (40 mg/m²) were normalized to 160 mg/m². c Boxplots of AUC_T0−∞ per weight quartile of observed AUC_T0−∞. d Boxplots of observed AUC_T0−∞ stratified for renal function. HCT hematopoietic cell transplantation, eGFR estimated glomerular filtration rate