Table 1.
Patient characteristics
| Children and adolescents (≤ 20 years) | Adults (> 20 years) | Total | |
|---|---|---|---|
| Available data | |||
| No. of patients [n (%)]a | 134 (52) | 124 (48) | 258 (100) |
| Total no. of pharmacokinetic samples [n (%)]a | 1384 (53) | 1221 (47) | 2605 (100) |
| No. of samples per patientb | 10 (3–19) | 10 (3–16) | 10 (3–19) |
| Patient characteristics | |||
| Female sex [n (%)]c | 52 (39) | 46 (37) | 98 (38) |
| Age at transplantation, yearsd | 9.6 (0.2–20, 2.7–14) | 54 (22–74, 40–62) | 18 (0.2–74, 40–62) |
| Actual bodyweight, kgd | 29 (4.3–96, 14–52) | 78 (47–130, 65–89) | 60 (4.3–130, 28–78) |
| Renal functiond [eGFR: mL/min/1.73 m2]d | 140 (40–140, 110–140) | 110 (25–140, 93–130) | 120 (25–140, 100–140) |
| Indication for transplantation [n (%)]c | |||
| Benign disorder | 65 (49) | 4 (3.2) | 69 (27) |
| Leukemia | 69 (51) | 48 (39) | 117 (45) |
| Lymphoma | 0 (0) | 17 (14) | 17 (6.6) |
| Myelodysplastic syndrome | 0 (0) | 32 (26) | 32 (12) |
| Plasma cell disorder | 0 (0) | 23 (19) | 23 (8.9) |
| Transplant cell source [no.(%)]c | |||
| Peripheral blood | 2 (2) | 109 (88) | 111 (43) |
| Cord blood | 94 (70) | 12 (10) | 106 (41) |
| Bone marrow | 38 (28) | 3 (2) | 41 (16) |
eGFR estimated glomerular filtration rate
aPercentage of full data
bData are expressed as median (range)
cPercentage of subgroup data within selected population (adults/children/total)
dData are expressed as median (range, interquartile range)
eCalculated as described in the Methods, Sect. 2.5