Table 2.

Final population pharmacokinetic parameter estimates

	Estimate (95% CIa)	Shrinkage	Bootstrap outcomesb
			Median	2.5th and 97.5th percentiles
Structural model
$\text{Cl}=({\text{Cl}}_{70\text{kg}-\text{non}-\text{renal}}+\text{eGFR}\times {\text{Slope}}_{\text{pop}})\times {\left(\frac{\text{BW}}{70\text{kg}}\right)}^{0.75}$
Cl70 kg-non-renal (L/h)	3.2 (1.6–4.9)		3.2	2.0–4.3
Slopepop	0.78 (0.57–1.0)		0.79	0.65–0.95
$V_1=V_{1,70\text{kg}}\times {\left(\frac{\text{BW}}{70\text{kg}}\right)}^1$
V1,70 kg (L)	39 (33–45)		39	33–46
$V_{2,\text{pop}}=V_{2,70\text{kg}}\times {\left(\frac{{\text{BW}}_{\text{i}}}{70\text{kg}}\right)}^1$
V2,70 kg (L)	20 (17–24)		21	16–28
$V_3=V_{3,70\text{kg}}\times {\left(\frac{\text{BW}}{70\text{kg}}\right)}^1$
V3,70 kg (L)	50 (41–58)		51	43–64
$Q_2=Q_{2,70\text{kg}}\times {\left(\frac{\text{BW}}{70\text{kg}}\right)}^{0.75}$
Q2,70 kg (L/h)	8.6 (6.8–10)		8.8	7.3–11
$Q_3=Q_{3,70\text{kg}}\times {\left(\frac{{\text{BW}}_{\text{i}}}{70\text{kg}}\right)}^{0.75}$
Q3,70 kg (L/h)	3.8 (2.9–4.6)		3.7	2.4–5.0
Random variability
Interindividual variability on CL, Q2, Q3 (%)	23 (15–31)	7%	23	20–26
Interindividual variability on V1, V2, V3 (%)	48 (36–60)	15%	47	37–57
Interoccasion variability on CL, Q2, Q3 (%)	12 (9.6–14)	28%	12	11–14
Interoccasion variability on V1, V2, V3 (%)	31 (18–44)	37%	32	25–38
Proportional residual error (%)	6.3 (4.3–8.3)	20%	6.2	5.4–7.2

CI confidence interval, pop population, i individual, BW actual body weight, V₁ central volume of distribution, V2 peripheral volume of distribution, V3 second peripheral volume of distribution, Q2 intercompartmental clearance V1–V2, Q3 intercompartmental clearance V1–V3

Population estimates V_1,70kg, V_2,70kg, V_3,70kg, Cl_70kg, Q_2,70kg, Q_3,70kg correspond to a subject weighing 70 kg and are adjusted to an individual value, according to the corresponding parameter formula in the table

^aCalculated from the residual standard error estimated from the covariance step

^bBased on 1000 bootstrap samples, of which 95% were successful