Table 2.

Independent SNP Associations with Risk of COA Discovered in the UK Biobank Study (13,962 Affected Individuals versus 300,671 Controls) and Validated in the 23andMe Study (31,759 Affected Individuals versus 214,890 Controls)

Chr	bp	Sentinel SNP	Context	A1	Discovery (UK Biobank)				Replication (23andMe)			Meta-Analysis
					OR	SE	P value	A1 freq	OR	SE	P value	OR	SE	P value
Sentinel SNPs that Represent Novel Associations for Allergic Disease
1	9356676	rs67551275	[SPSB1]	T	1.071	0.012	1.3E-08	0.53	1.067	0.010	5.9E-11	1.069	0.008	3.8E-18
1	172715702	rs78037977	FASLG-[]–TNFSF18	A	1.116	0.018	1.4E-09	0.88	1.066	0.015	1.6E-05	1.086	0.011	6.2E-13
1	213056427	rs12750027	[FLVCR1]	A	1.150	0.024	3.9E-09	0.07	1.075	0.022	1.4E-03	1.109	0.016	2.6E-10
2	224664050	rs6755248	[AP1S3]	G	1.070	0.012	1.6E-08	0.41	1.046	0.009	1.3E-06	1.055	0.007	3.2E-13
2	228670437	rs10187276	SLC19A3-[]-CCL20	T	1.116	0.014	7.0E-16	0.25	1.059	0.011	6.2E-08	1.079	0.009	1.5E-19
3	127912846	rs11412402	[EEFSEC]	D	1.073	0.012	3.2E-09	0.47	1.047	0.009	4.9E-07	1.057	0.007	3.9E-14
3	176852038	rs7626218	[TBL1XR1]	A	1.083	0.012	3.1E-11	0.60	1.031	0.009	1.5E-03	1.051	0.007	3.6E-11
6	409119	rs9391997	[IRF4]	G	1.077	0.012	3.1E-10	0.53	1.038	0.009	5.9E-05	1.052	0.007	3.8E-12
7	22780322	rs6954667	IL6-[]-TOMM7	A	1.074	0.013	2.6E-08	0.31	1.028	0.010	6.0E-03	1.045	0.008	3.0E-08
8	120063542	rs2450083	TNFRSF11B-[]-COLEC10	C	1.070	0.012	1.1E-08	0.50	1.037	0.009	1.2E-04	1.049	0.007	7.8E-11
9	23585839	rs274943	DMRTA1—[]–ELAVL2	T	1.080	0.012	9.1E-11	0.52	1.051	0.009	6.8E-08	1.062	0.007	2.6E-16
10	6093139	rs12722502	[IL2RA]	C	1.326	0.044	2.0E-10	0.98	1.235	0.053	4.3E-05	1.288	0.034	6.8E-14
10	6621773	rs943451	[PRKCQ]	T	1.105	0.013	7.5E-15	0.31	1.041	0.010	4.7E-05	1.063	0.008	3.5E-15
10	94384514	rs113092121	[KIF11]	I	1.092	0.012	1.8E-13	0.56	1.058	0.009	1.8E-09	1.070	0.007	2.5E-20
11	10664033	rs2052690	[MRVI1]	T	1.077	0.013	1.5E-08	0.29	1.043	0.010	3.2E-05	1.056	0.008	1.1E-11
11	36365253	rs10836538	[PRR5L]	G	1.083	0.012	1.2E-10	0.65	1.040	0.010	5.4E-05	1.057	0.007	2.7E-13
12	55368291	rs62623446	[TESPA1]	T	1.138	0.023	1.7E-08	0.07	1.103	0.021	6.2E-06	1.119	0.016	8.0E-13
13	99974492	rs1887704	[UBAC2]	G	1.102	0.013	1.4E-14	0.68	1.059	0.010	4.8E-09	1.075	0.008	4.7E-20
16	27349168	rs3785356	[IL4R]	T	1.116	0.013	2.7E-17	0.29	1.073	0.010	2.5E-12	1.089	0.008	8.5E-27
16	50745926	rs2066844	[NOD2]	T	1.172	0.028	1.5E-08	0.05	1.086	0.022	2.5E-04	1.119	0.017	1.3E-10
18	48647640	rs1893380	SMAD4-[]-MEX3C	C	1.083	0.012	5.2E-11	0.38	1.039	0.009	5.7E-05	1.055	0.007	3.6E-13
18	51816408	rs12965763	[POLI]	A	1.100	0.014	2.3E-11	0.22	1.034	0.011	2.3E-03	1.059	0.009	4.3E-11
19	1152656	rs892225	[SBNO2]	G	1.080	0.012	3.4E-10	0.38	1.040	0.010	9.7E-05	1.057	0.008	1.1E-12
X	13023741	rs850637	TMSB4X-[]-FAM9C	G	1.064	0.010	2.2E-10	0.56	1.036	0.008	3.3E-06	1.046	0.006	8.3E-14
X	49139787	rs5953283	[PPP1R3F]	A	1.064	0.010	3.1E-10	0.40	1.024	0.008	2.2E-03	1.038	0.006	5.6E-10
Sentinel SNPs in LD (r2 > 0.05) with Variants Previously Reported to Associate with Allergic Disease
1	151801680	rs4845604	[RORC]	G	1.140	0.017	9.5E-15	0.86	1.062	0.014	9.2E-06	1.092	0.011	1.5E-16
1	152179152	rs12123821	RPTN-[]-HRNR	T	1.523	0.028	4.0E-51	0.05	1.163	0.025	1.1E-09	1.307	0.018	7.6E-48
1	161185058	rs2070901	NDUFS2-[]-FCER1G	T	1.093	0.013	2.4E-11	0.27	1.105	0.010	4.2E-22	1.100	0.008	2.8E-32
1	167436270	rs1617333	[CD247]	A	1.098	0.012	9.9E-15	0.60	1.061	0.009	4.3E-10	1.075	0.007	2.5E-22
1	173131493	rs10158467	TNFSF18–[]-TNFSF4	G	1.116	0.013	6.3E-17	0.28	1.079	0.010	5.0E-14	1.093	0.008	8.3E-29
1	203093201	rs12023876	MYOG-[]-ADORA1	G	1.080	0.012	7.8E-10	0.67	1.071	0.010	4.3E-12	1.074	0.008	4.9E-21
2	8459404	rs3856439	[LINC00299]	C	1.113	0.012	6.0E-18	0.66	1.070	0.010	7.0E-12	1.087	0.008	6.2E-28
2	102798245	rs74180212	IL1R1-[]-IL1RL2	G	1.123	0.012	1.1E-20	0.44	1.087	0.010	1.6E-17	1.101	0.008	5.3E-37
2	102882352	rs78545931	IL1RL2-[]-IL18R1	A	1.408	0.033	4.2E-25	0.98	1.391	0.027	5.9E-37	1.398	0.021	8.8E-59
2	102936159	rs72823641	[IL18R1]	T	1.341	0.017	6.9E-68	0.86	1.281	0.014	5.4E-75	1.305	0.011	2E-136
2	102966906	rs1861245	[IL1RL1]	C	1.194	0.013	9.3E-45	0.66	1.124	0.010	3.9E-32	1.150	0.008	2.3E-69
2	112268732	rs143326447	BCL2L11–[]–ANAPC1	C	1.108	0.018	1.8E-08	0.12	1.047	0.015	2.0E-03	1.071	0.011	1.8E-09
2	242698640	rs34290285	[D2HGDH]	G	1.198	0.013	3.3E-41	0.74	1.142	0.012	5.5E-29	1.168	0.009	4.2E-69
3	33047662	rs35570272	[GLB1]	T	1.106	0.012	7.8E-17	0.39	1.029	0.009	2.3E-03	1.057	0.007	4.1E-14
3	121716171	rs1806656	[ILDR1]	C	1.082	0.013	6.3E-10	0.68	1.036	0.010	6.4E-04	1.053	0.008	1.2E-10
3	141150026	rs7625643	[ZBTB38]	G	1.070	0.012	2.1E-08	0.44	1.029	0.009	2.7E-03	1.044	0.007	4.9E-09
3	188128979	rs9860547	[LPP]	A	1.135	0.012	1.9E-26	0.45	1.087	0.009	1.5E-19	1.105	0.007	3.6E-42
3	188401138	rs55661102	[LPP]	A	1.101	0.016	9.0E-10	0.83	1.093	0.013	2.4E-12	1.096	0.010	4.1E-20
4	38798648	rs5743618	[TLR1]	C	1.210	0.014	2.1E-43	0.76	1.141	0.011	1.7E-36	1.165	0.008	3.2E-74
4	123353432	rs17454584	ADAD1-[]-IL2	G	1.126	0.014	1.5E-16	0.21	1.106	0.011	2.1E-20	1.114	0.009	5.9E-36
5	14610309	rs16903574	[FAM105A]	G	1.191	0.023	2.1E-14	0.07	1.122	0.017	7.9E-12	1.145	0.013	1.0E-23
5	110158844	rs7734635	SLC25A46-[]–TSLP	G	1.176	0.016	3.7E-23	0.15	1.084	0.012	1.8E-11	1.116	0.009	1.9E-30
5	110401872	rs1837253	SLC25A46–[]-TSLP	C	1.182	0.013	1.2E-35	0.74	1.189	0.011	1.6E-59	1.186	0.008	7.1E-94
5	110470137	rs6594499	WDR36-[]-CAMK4	C	1.147	0.012	3.3E-31	0.51	1.126	0.009	5.4E-38	1.134	0.007	3.9E-66
5	131799626	rs3749833	[C5orf56]	C	1.109	0.013	1.3E-14	0.26	1.057	0.011	2.2E-07	1.077	0.008	1.2E-19
5	131916940	rs2299012	[RAD50]	C	1.191	0.015	1.9E-31	0.19	1.115	0.011	7.6E-23	1.141	0.009	1.0E-49
5	132105698	rs113010607	[SEPT8]	C	1.172	0.022	4.1E-13	0.07	1.101	0.017	6.1E-09	1.126	0.013	2.0E-19
5	141533062	rs449454	[NDFIP1]	G	1.084	0.012	3.0E-11	0.62	1.070	0.010	1.1E-12	1.076	0.007	2.0E-22
6	31303324	rs114444221	[HLA-B]	A	1.231	0.027	2.3E-14	0.97	1.095	0.017	1.2E-07	1.133	0.015	9.0E-18
6	33033824	rs111789468	[HLA-DPA1]	T	1.222	0.030	1.3E-11	0.03	1.069	0.013	4.1E-07	1.092	0.012	2.2E-13
6	33099538	rs3116989	HLA-DPB2-[]-COL11A2	G	1.151	0.017	5.3E-16	0.87	1.060	0.014	3.2E-05	1.096	0.011	2.6E-17
6	90976609	rs62408233	[BACH2]	G	1.113	0.012	2.9E-18	0.64	1.096	0.010	3.3E-21	1.103	0.008	2.8E-38
6	106667535	rs9372120	[ATG5]	G	1.106	0.015	5.5E-12	0.21	1.078	0.011	4.2E-11	1.088	0.009	8.8E-21
6	128293562	rs55743914	[PTPRK]	T	1.105	0.014	4.8E-13	0.24	1.051	0.011	5.0E-06	1.071	0.009	1.5E-15
6	138002175	rs6927172	OLIG3–[]–LOC100130476	C	1.090	0.014	1.4E-09	0.78	1.051	0.011	1.1E-05	1.067	0.009	3.3E-13
7	20423923	rs149317277	[ITGB8]	D	1.087	0.012	6.6E-12	0.61	1.050	0.009	3.0E-07	1.064	0.007	8.4E-17
7	20544209	rs12531500	ITGB8-[]–ABCB5	A	1.103	0.012	1.8E-16	0.57	1.056	0.009	5.3E-09	1.073	0.007	6.7E-22
7	28156606	rs4722758	[JAZF1]	G	1.126	0.015	6.2E-16	0.20	1.090	0.011	6.1E-15	1.103	0.009	2.8E-28
8	81294702	rs2221641	MIR5708–[]–ZBTB10	C	1.112	0.012	2.4E-18	0.38	1.074	0.009	2.2E-14	1.088	0.007	1.8E-30
8	128777719	rs13277355	POU5F1B–[]-MYC	A	1.103	0.013	1.4E-13	0.27	1.072	0.010	7.1E-12	1.084	0.008	9.5E-24
9	6081804	rs340934	RANBP6-[]–IL33	T	1.208	0.015	1.6E-36	0.81	1.142	0.012	8.7E-30	1.167	0.009	3.1E-62
9	6213468	rs7848215	RANBP6–[]-IL33	T	1.255	0.014	4.1E-63	0.25	1.181	0.010	1.3E-59	1.206	0.008	5E-115
10	8606014	rs17144046	GATA3–[]—SFTA1P	G	1.102	0.013	7.0E-13	0.28	1.044	0.010	3.3E-05	1.066	0.008	2.9E-15
10	9049253	rs12413578	GATA3—[]—SFTA1P	C	1.204	0.019	1.7E-22	0.89	1.160	0.016	7.7E-21	1.178	0.012	9.1E-41
10	9064716	rs1612986	GATA3—[]—SFTA1P	C	1.168	0.015	4.5E-24	0.18	1.110	0.012	8.3E-19	1.131	0.009	8.3E-41
10	64391375	rs10995245	[ZNF365]	A	1.073	0.012	1.3E-08	0.35	1.033	0.010	9.2E-04	1.048	0.007	3.6E-10
11	65551957	rs479844	AP5B1-[]-OVOL1	G	1.116	0.012	1.4E-20	0.55	1.052	0.009	3.9E-08	1.075	0.007	3.2E-23
11	76299431	rs55646091	WNT11–[]-LRRC32	A	1.513	0.028	3.9E-50	0.05	1.283	0.021	8.5E-30	1.364	0.017	5.9E-74
11	76299649	rs11236797	WNT11–[]-LRRC32	A	1.214	0.012	2.4E-60	0.45	1.132	0.009	1.0E-41	1.162	0.007	1E-93
11	118743286	rs12365699	DDX6-[]-CXCR5	G	1.141	0.016	6.1E-17	0.83	1.106	0.013	4.2E-16	1.119	0.010	4.3E-30
11	128172836	rs140522418	KIRREL3-AS3—[]–ETS1	D	1.095	0.015	4.8E-09	0.82	1.039	0.012	1.9E-03	1.062	0.010	4.3E-10
12	56389293	rs705700	[RAB5B]	C	1.108	0.012	8.1E-18	0.42	1.060	0.009	4.3E-10	1.078	0.007	2.5E-24
12	57509102	rs3122929	[STAT6]	T	1.141	0.012	7.6E-28	0.40	1.067	0.009	5.7E-12	1.095	0.007	2.4E-34
12	112059557	rs11065979	ATXN2-[]-BRAP	C	1.085	0.012	6.5E-12	0.56	1.054	0.009	1.3E-08	1.066	0.007	4.8E-18
12	121365431	rs188074962	SPPL3-[]-HNF1A-AS1	G	1.112	0.012	8.8E-18	0.35	1.048	0.010	1.9E-06	1.073	0.008	1.6E-20
12	123635096	rs1716183	[PITPNM2]	C	1.098	0.016	2.2E-09	0.83	1.049	0.013	1.2E-04	1.067	0.010	3.5E-11
14	68754695	rs1885013	[RAD51B]	G	1.098	0.013	1.0E-12	0.28	1.078	0.010	4.4E-14	1.085	0.008	2.9E-25
14	103244070	rs71421264	[TRAF3]	G	1.081	0.012	1.0E-10	0.59	1.032	0.009	7.2E-04	1.050	0.007	2.8E-11
15	41787585	rs1655558	[ITPKA]	G	1.087	0.012	2.8E-12	0.55	1.056	0.010	1.7E-08	1.068	0.007	2.2E-18
15	61069988	rs11071559	[RORA]	C	1.185	0.017	1.9E-22	0.87	1.121	0.014	2.5E-17	1.145	0.011	2.0E-37
15	67441750	rs72743461	[SMAD3]	A	1.196	0.014	1.7E-37	0.23	1.127	0.011	3.8E-29	1.152	0.009	6.4E-63
15	67475764	rs34445740	[SMAD3]	D	1.111	0.013	4.7E-16	0.70	1.055	0.010	1.8E-07	1.076	0.008	7.7E-20
16	11219041	rs12935657	[CLEC16A]	G	1.154	0.014	6.1E-26	0.75	1.122	0.011	1.3E-27	1.133	0.009	1.0E-49
17	38061439	rs4795399	[GSDMB]	T	1.303	0.012	3E-111	0.53	1.280	0.009	2E-155	1.289	0.007	1E-257
17	38064971	rs117097909	[GSDMB]	A	1.355	0.026	1.5E-31	0.05	1.247	0.022	3.7E-22	1.292	0.017	1.6E-51
17	38755021	rs9893132	CCR7-[]-SMARCE1	G	1.095	0.012	1.4E-13	0.64	1.047	0.010	1.7E-06	1.065	0.007	3.0E-17
17	38764524	rs112401631	CCR7-[]-SMARCE1	A	1.354	0.043	1.6E-12	0.02	1.265	0.044	1.9E-07	1.310	0.031	2.1E-18
17	43457886	rs9895436	MAP3K14-[]-ARHGAP27	A	1.089	0.012	1.8E-12	0.40	1.058	0.009	1.4E-09	1.070	0.007	5.9E-20
17	47448346	rs12952581	ZNF652-[]-PHB	A	1.094	0.012	2.4E-13	0.36	1.069	0.010	3.2E-12	1.078	0.007	4.4E-24
18	60009814	rs4574025	[TNFRSF11A]	T	1.092	0.012	1.3E-13	0.53	1.036	0.010	2.2E-04	1.058	0.007	8.0E-14
18	61442619	rs12964116	[SERPINB7]	G	1.293	0.031	3.0E-16	0.04	1.143	0.041	1.1E-03	1.236	0.025	8.4E-18
19	8785744	rs2918302	ADAMTS10–[]-ACTL9	A	1.107	0.016	5.8E-10	0.15	1.037	0.013	3.5E-03	1.064	0.010	4.8E-10
19	33726578	rs117710327	SLC7A10-[]-CEBPA	C	1.205	0.024	4.7E-15	0.94	1.189	0.021	1.2E-16	1.196	0.016	2.8E-29