Table 1.
Demographics and serum IL‐1 family cytokines in SSc and HC
| HC (N = 47) | SSc (N = 105) | P‐value | |
|---|---|---|---|
| Demographics | |||
| Age (years), mean (SD) | 37.6 (10.6) | 60.1 (13.9) | < 0.01 |
| Female, n (%) | 34 (72.3%) | 87 (82.9%) | 0.14 |
| Ethnicitya, n (%) | |||
| Caucasian | 33 (70.2%) | 86 (83.5%) | 0.09 |
| Asian | 11 (23.4%) | 10 (9.7%) | |
| Other | 3 (6.4%) | 7 (6.8%) | |
| Serum cytokines | |||
| Detectable IL‐1α, n (%) | 35 (74.5%) | 78 (74.3%) | 0.98 |
| IL‐1α (pg mL−1), median [IQR] | 3 [2, 41]b | 11 [2, 29]c | 0.51 |
| Detectable IL‐1β, n (%) | 26 (55.3%) | 68 (64.8%) | 0.27 |
| IL‐1β (pg mL−1), median [IQR] | 5 [1, 16] | 7 [1, 17] | 0.37 |
| Detectable IL‐18, n (%) | 47 (100%) | 103 (98.1%) | 0.9 |
| IL‐18 (pg mL−1), median [IQR] | 183 [135, 258] | 265 [183, 362]d | < 0.01 |
HC, healthy controls; IL, interleukin; SSc, systemic sclerosis.
a
Two missing values in the SSc cohort.
b
N = 42; When including 5 HC with serum IL‐1α concentrations higher than uLOD (N = 47): median [IQR] serum IL‐1α concentrations 19 [2, 70]; P = 0.9.
c
N = 87; When including 18 SSc patients with serum IL‐1α concentrations higher than uLOD (N = 105): median [IQR] serum IL‐1α concentrations 17 [2, 87]; P = 0.9.
d
N = 103; When including 2 SSc patients with serum IL‐18 concentrations higher than uLOD (N = 105): median [IQR] serum IL‐18 concentrations 266 [191, 362]; P < 0.01.