Table 2. Association of preoperative serum SPINK4 level with clinical features in CRC.

	Expression value	p-value
Age (years)		0.759
>60 years	5.03 ± 3.06
≤ 60 years	4.79 ± 3.41
Gender		0.366
Male	5.16 ± 3.50
Female	4.48 ± 2.68
T stage		0.882
T1+T2	4.73 ± 1.85
T3+T4	4.92 ± 3.28
N stage		0.163
N0	5.58 ± 0.47
N1+N2	4.88 ± 3.29
M stage		0.021
M0	3.79 ± 2.72
M1	5.53 ± 3.33
Grade		0.589
Low	5.40 ± 4.09
High+ middle	4.78 ± 2.97
Location		0.002
Colon	5.42 ± 3.58
Rectal	3.54 ± 1.16

Notes.

The differences among groups were compared using Student’s t-test.