Table 1.
Top 60 most enriched gene sets in alveolar macrophages after allergen provocation.
| Pathways Up-regulated in Alveolar Macrophages Post Challenge (n = 30) | FDR |
| Class a1 rhodopsin like receptors | 0 |
| G-protein coupled receptor (GPCR) ligand binding | 0 |
| Cytokine cytokine receptor interaction | 0 |
| Allograft rejection | 0 |
| Inflammatory response | 0 |
| Hematopoietic cell lineage | 0 |
| Suppressed in response to AZM | 0 |
| Induced in response to IL-4 | 0 |
| Signaling by GPCR | 0 |
| Neuroactive ligand receptor interaction | 0 |
| GPCR downstream signaling | 0 |
| Suppressed in response to MP | 0 |
| IL-2 Stat5 signaling | 0 |
| Chemokine receptors bind chemokines | 0 |
| TNFa signaling via NF-kB | 0 |
| Immunoregulatory interactions between a lymphoid and a non lymphoid cell | 0 |
| Peptide ligand binding receptors | 0 |
| Gastrin creb signaling pathway via PKC and MAPK | 0 |
| Induced in response to IL-10 | 0 |
| G alpha (q) signaling events | 0 |
| CDB T-cell receptor pathway | 3.68×10−5 |
| Srp-dependent cotranslational protein targeting to membrane | 3.51×10−5 |
| Core matrisome | 1.01×10−4 |
| G2M checkpoint | 1.28×10−4 |
| CDB T-cell receptor downstream pathway | 2.18×10−4 |
| T-cell receptor signaling pathway | 2.71×10−4 |
| IL-12 pathway | 5.54×10−4 |
| T cytotoxic pathway | 1.06×10−3 |
| T-cell signal transduction | 1.12×10−3 |
| IL-17 pathway | 1.73×10−3 |
| Pathways Down-regulated in Alveolar Macrophages Post Challenge (n = 30) | FDR |
| Generic transcription pathway | 0 |
| Interferon alpha response | 0 |
| Oxidative phosphorylation | 0 |
| Metabolism of lipids and lipoproteins | 0 |
| Suppressed in response to IL-4 | 0 |
| Fatty acid metabolism | 0 |
| Adipogenesis | 0 |
| Peroxisome | 0 |
| Induced in response to MP | 0 |
| Interferon gamma response | 0 |
| Cholesterol homeostasis | 0 |
| Cholesterol biosynthesis | 0 |
| Induced in response to AZM | 0 |
| Pyruvate metabolism | 0 |
| Transcription | 0 |
| Aminoacyl tRNA biosynthesis | 0 |
| Phospholimetabolism | 0 |
| DNA repair | 6.40×10−5 |
| p53 pathway | 6.06×10−5 |
| Coagulation | 5.76×10−5 |
| Spliceosome | 5.48×10−5 |
| Valine leucine and isoleucine degradation | 5.23×10−5 |
| Recruitment of mitotic centrosome proteins and complexes | 5.01×10−5 |
| Interferon alpha beta signaling | 9.89×10−5 |
| Platelet sensitization by LDL | 2.38×10−4 |
| mRNA processing | 5.07×10−4 |
| Antigen processing ubiquitination proteasome degradation | 4.88×10−4 |
| Interferon gamma signaling | 5.13×10−4 |
| Suppressed in response to IL-10 | 6.79×10−4 |
| Glycan degradation | 9.73×10−4 |