Table 3.
Biodistribution results of [99mTc]TcO-KYCAR(syn) in healthy mice (n=5). The results are reported in %ID/g. Shows that the activity travels through the gastrointestinal track. Also shows some decomposition to potential 99mTcO4− products as seen with thyroid accumulation.
| [99mTcO]-KYCAR(syn), %ID/g ± S.D. | ||||
|---|---|---|---|---|
| Organ | 0.5 h | 1 h | 2 h | 4 h |
| Blood | 1.77 ± 0.37 | 1.37 ± 0.14 | 1.08 ± 0.20 | 0.91 ± 0.04 |
| Heart | 0.66 ± 0.60 | 0.42 ± 0.05 | 0.58 ± 0.22 | 0.33 ± 0.06 |
| Lungs | 1.39 ±0.23 | 1.13 ± 0.18 | 1.52 ± 0.98 | 0.99 ± 0.38 |
| Liver | 22.10 ± 4.80 | 13.35 ± 1.85 | 4.37 ± 1.55 | 1.83 ± 0.19 |
| Spleen | 0.82 ± 0.25 | 0.69 ± 0.13 | 0.57 ± 0.18 | 0.44 ± 0.17 |
| Stomach | 4.57 ±0.86 | 5.06 ± 1.33 | 5.83 ± 2.10 | 4.07 ± 1.03 |
| Small Intestine | 22.82 ± 3.66 | 30.49 ± 10.05 | 21.18 ±10.14 | 3.62 ± 1.28 |
| Large Intestine | 0.31 ± 0.07 | 0.30 ± 0.04 | 1.82 ± 1.81 | 36.77 ± 10.76 |
| Kidneys | 5.95 ± 0.60 | 5.58 ± 0.85 | 5.09 ± 0.50 | 4.87 ± 0.54 |
| Muscle | 0.25 ±0.11 | 0.24 ± 0.10 | 0.19 ± 0.01 | 0.24 ± 0.12 |
| Bone | 0.71 ± 0.15 | 0.59 ± 0.16 | 0.53 ± 0.32 | 0.50 ± 0.18 |
| Skin | 1.12 ± 0.36 | 0.57 ± 0.06 | 0.49 ± 0.11 | 0.47 ± 0.07 |
| Thyroid | 38.44 ± 11.07 | 118.75 ± 15.13 | 116.71 ± 23.20 | 146.44 ± 42.20 |
| Gall Bladder | 590.36 ± 274.09 | 840.72 ± 523.07 | 206.78 ± 104.24 | 164.07 ± 136.89 |